| Bioactivity | EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase[1]. |
| Target | IC50: 1.5 nM (EGFR) |
| Name | EGFR-IN-86 |
| Formula | C20H21N7O2S |
| Molar Mass | 423.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Y, et al. Design and discovery of novel pyrazole-pyrrolopyrimidine derivatives as anti-glioma agents via promoting apoptosis, inhibiting cell cycle and EGFR-TK. Chem Biol Drug Des. 2023 Aug 28.. . |