EGFR-IN-59

CAS: 2529891-44-7 F: C27H23N5O4S W: 513.57

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity again

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Bioactivity	EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1].
Invitro	EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) [1]. Cell Cytotoxicity Assay[1] Cell Line:
Name	EGFR-IN-59
CAS	2529891-44-7
Formula	C27H23N5O4S
Molar Mass	513.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.