| Bioactivity | EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1]. |
| Invitro | EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 µM, respectively[1].EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells[1].EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | EGFR-IN-46 |
| CAS | 2764772-88-3 |
| Formula | C27H32F3N3O3 |
| Molar Mass | 503.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
EGFR-IN-46
CAS: 2764772-88-3 F: C27H32F3N3O3 W: 503.56
EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significan
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