| Bioactivity | EGFR-IN-148 (compound 8c) is a potent inhibitor of EGFR , with the IC50 of 0.161 μM. EGFR-IN-148 causes G1/S arrest and markedly enhances apoptosis in HepG2 cells[1]. |
| Formula | C17H16N4O4S |
| Molar Mass | 372.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mahmoud S. Elkotamy, et al. Design, synthesis, and molecular dynamics-driven evaluation of quinoline-sulfonamide derivatives as potent and selective EGFR inhibitors with promising anti-cancer efficacy and safety profiles. Bioorganic Chemistry Available online 5 February 2025, 108247 |