| Bioactivity | EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC)[1]. |
| Invitro | EGFR-IN-127 (compound b) 抑制肺癌细胞 A549、PC-9del19、PC-9del19/T790M/C797S 和 H1975 细胞的增殖，IC50 值分别为 0.9464 μM、1.1262 μM、0.4963 μM 和 1.4142 μM[1]。EGFR-IN-127 (100 nM-1 μM；48小时) 显示出明显的细胞迁移抑制[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EGFR-IN-127 相关抗体: Cell Migration Assay [1] Cell Line: |
| Formula | C24H24FN7O6 |
| Molar Mass | 525.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liang-Liang Guo, et al. Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines. Bioorg Med Chem Lett. 2024 Sep 14:113:129961. |