| Bioactivity | EGFR-IN-112 (SPP10) is an EGFR kinase inhibitor which exhibits IC50s of 2.31 ± 0.3, 3.16 ± 0.8, and 4.2 ± 0.2 μM, against MCF-7, H69AR, and PC-3 cancer cells, respectively. EGFR-IN-112 also demonstrates selective cytotoxicity against cancer cells[1]. |
| Invitro | EGFR-IN-112 (IC50, 72 h) 显著抑制 MCF-7、H69AR 和 PC-3 细胞的 Bcl-2，同时诱导 Bax 和 Cyt-c[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EGFR-IN-112 相关抗体: |
| CAS | 2758436-98-3 |
| Formula | C27H23N3S |
| Molar Mass | 421.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Harika A, et al. Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis. ACS Omega Article ASAP |