| Bioactivity | EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects[1]. |
| Invitro | Ru4S (0.2-100 μM; 48 h) 对 HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T 细胞系具有细胞毒性，IC50 值分别为 23.76, 2.47, 6.24, 5.35, 29.90, 33.15 μM[1]。Ru4S (0.78-50 μM; 48 h) 诱导 HepG2 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EGFR-IN-108 chloride 相关抗体: Cell Cytotoxicity Assay Cell Line: |
| Formula | C45H40Cl3F3N8O3Ru |
| Molar Mass | 1005.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zengin Kurt B, et al. Synthesis of Sorafenib-Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent. J Med Chem. 2024 Mar 12. |
EGFR-IN-108 chloride
CAS: F: C45H40Cl3F3N8O3Ru W: 1005.28
EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride i
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