| Bioactivity | ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. ED11 competes with Htt for the caspase-6 active site, and thus reduce Htt cleavage. ED11 can cross the blood-brain barrier (BBB). ED11 has the potential for the study of Huntington's disease (HD)[1]. |
| CAS | 1593480-56-8 |
| Sequence | Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-Ser-Ser-Glu-Ile-Val-Leu-Asp-Gly-Thr-Asp-Asn |
| Shortening | GRKKRRQRRRPPQSSEIVLDGTDN |
| Formula | C116H205N47O37 |
| Molar Mass | 2850.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aharony I, et al. A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits. Hum Mol Genet. 2015 May 1;24(9):2604-14. |
ED11
CAS: 1593480-56-8 F: C116H205N47O37 W: 2850.16
ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. ED11 competes with Htt for the caspase-6 ac
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