| Bioactivity | Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2]. | ||||||||||||
| Invitro | Dp44mT (compound C7) (0-80 μM, 48 h) 呈细胞系依赖的方式诱导裂解周期，对 AGS-BX1 细胞的诱导能力高于 AGX 细胞[1]。Dp44mT (10 μM, 0-72 h) 呈时间依赖方式诱导裂解循环[1]。Dp44mT (1.25-2.5 μM, 24 h) 可与 HDAC 抑制剂 Romidespin 和 SAHA 协同诱导 EBV 裂解循环[1]。Dp44mT (20 μM, 48 h) 通过诱导 ERK-自噬 (autophage) 轴来重新激活 EBV 裂解周期[2]。 0 --> EBV lytic cycle inducer-1 相关抗体: Immunofluorescence[1] Cell Line: | ||||||||||||
| Name | EBV lytic cycle inducer-1 | ||||||||||||
| CAS | 394668-43-0 | ||||||||||||
| Formula | C14H12BrN3O | ||||||||||||
| Molar Mass | 318.17 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994. [2]. Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505. |
EBV lytic cycle inducer-1
CAS: 394668-43-0 F: C14H12BrN3O W: 318.17
Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates
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