| Bioactivity | EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells[1]. | ||||||||||||
| Target | EC50: 0.31 µM (EBOV), 0.82 µM (MARV) | ||||||||||||
| Invitro | EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088)[1]. | ||||||||||||
| Name | EBOV/MARV-IN-1 | ||||||||||||
| CAS | 2479465-67-1 | ||||||||||||
| Formula | C25H30F3N3O2 | ||||||||||||
| Molar Mass | 461.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225. |
EBOV/MARV-IN-1
CAS: 2479465-67-1 F: C25H30F3N3O2 W: 461.52
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=
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