EBOV-IN-5_product_DataBase

Bioactivity	EBOV-IN-5 (compound 14) is an antiviral agent that inhibits Ebola virus (EBOV) infection. EBOV-IN-5 inhibits the binding of the EBOV glycoprotein EBOV-GPcl to NPC1, an indispensable host receptor required for viral fusion/entry.[7][1].
Target	Ebola virus
Invitro	EBOV-IN-5 (compound 14) 对 HeLa 细胞的 CC50 为 30 μM，且对 Vero 细胞的细胞毒性低，CC50 >100 μM[1]。EBOV-IN-5 (50 μM) 显著干扰 EBOV-GPcl/NPC1 相互作用，对 EBOV-GP-假型病毒 (pEBOV) 的 IC50 为 4.69 μM[1]。EBOV-IN-5 对非洲猪瘟病毒 ASFV 的 IC50 为 35.17 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EBOV-IN-5 相关抗体:
CAS	68207-15-8
Formula	C18H21ClN4O3S
Molar Mass	408.90
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lasala F, et al. Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Res. 2021 Feb;186:105011.

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