Bioactivity | EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1]. | ||||||||||||
Target | EAAT2 | ||||||||||||
Name | EAAT2 activator 1 | ||||||||||||
CAS | 892415-28-0 | ||||||||||||
Formula | C16H11ClFN3S | ||||||||||||
Molar Mass | 331.80 | ||||||||||||
Appearance | Solid | ||||||||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage |
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Reference | [1]. Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21(19):5774-5777. |