| Bioactivity | EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis[1]. |
| Target | Ki: 130 μM (rPLA2) |
| Invitro | EA4（9 μM，24 μM）抑制 rPLA2 和 cPLA2[1]。EA4 可抑制 rPLA2，Ki 值为 130 μM[1]。EA4 (50 μM) 以时间依赖性方式显著抑制 A23187 诱导的人和牛红细胞释放 AA[1]。 |
| Name | EA4 |
| CAS | 389614-94-2 |
| Formula | C19H17ClN2O2 |
| Molar Mass | 340.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shin, Hae Sook et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells. The Journal of biological chemistry vol. 277,23 (2002): 21086-94. |