| Bioactivity | EA-89 is a potent and selective BRD9 inhibitor with antitumor activity. EA-89 is a Ligand for Target Protein for PROTAC. EA-89 can be used to synthesize PROTAC QA-68 (HY-150797)[1]. |
| Target | BRD9 |
| Invitro | EA-89 (0-3.2 μM；1-7 天) 在人类白血病细胞系中能抑制细胞增殖和 BRD9、c-MYC 和 c-MYB 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EA-89 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C31H38N4O4S2 |
| Molar Mass | 594.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Weisberg E, et al. BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma. Blood Cancer J. 2022 Jul 19;12(7):110. |