| Bioactivity | E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling[1]. |
| Invitro | E7130 抑制微管动力学，并在癌细胞 KPL-4，OSC-19，FaDu 和 HSC-2 中显示抗增殖活性，IC50 值分别为 0.01-0.1 nM[1]。E7130 (0.15 nM) 通过破坏微管网络的形成抑制 TGF-β 诱导的肌成纤维细胞转化，使 PI3K/AKT/mTOR 通路失活[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> E7130 相关抗体: Immunofluorescence[1] Cell Line: |
| In Vivo | E7130 (45-180 μg/kg，静脉注射) 增加肿瘤内微血管密度 (MVD)，从而增加 cetuximab (CTX) 向肿瘤的递送，导致 HSC-2 SCCHN 异种移植 BALB/c 小鼠中的肿瘤消退[1]。E7130 (45-180 μg/kg，静脉注射) 减少 α-SMA 阳性 CAF，E7130-CTX 组合可调节 FaDu SCCHN 异种移植 BALB/c 小鼠中成纤维细胞的表型[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C58H83NO17 |
| Molar Mass | 1066.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kawano S, et al., A landmark in drug discovery based on complex natural product synthesis. Sci Rep. 2019 Jun 17;9(1):8656. |