| Bioactivity | E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture[1]. |
| Sequence | {9-fluorenyl acetamido}-Ile-Pro-Gln-Ser-Ala-Glu-Leu-Thr-Leu-Gln-Glu-Leu-{Dha}-Arg-Arg-Lys-Lys-Lys(1-anthracenyl acetamido)-NH2 |
| Shortening | {9-fluorenyl acetamido}-IPQSAELTLQELL-{Dha}-RRKK-{Lys(1-anthracenyl acetamido)}-NH2 |
| Formula | C128H193N31O29 |
| Molar Mass | 2630.09 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiyun Ye, et al. Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. Chem Sci. 2023 Oct 25;14(44):12484-12497. |
E6AP-mimicking peptide
CAS: F: C128H193N31O29 W: 2630.09
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16
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