| Bioactivity | E3 ligase Ligand 45 is an E3 ligase ligand that can be used to synthesize the PROTAC degrader Setidegrasib (HY-148273) for Ras[1]. |
| Formula | C22H29N3O5S |
| Molar Mass | 447.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yoshinari, et al. Preparation of quinazoline-linked (4R)-4-hydroxy-L-prolinamide compounds for inducing degradation of G12D-mutation KRAS protein: World Intellectual Property Organization, WO2022173032[P]. 2022-08-18. |