| Bioactivity | E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation[1]. |
| Invitro | E3 ligase Ligand 24 (5μM; 24h) 处理 HiBiT 标签的 BRD4 的 HEK293细胞，可以有效降解 BRD4 蛋白，且该降解并非通过 DCAF15 介导。[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> E3 ligase Ligand 24 相关抗体: |
| Formula | C21H26Cl2N4O5S |
| Molar Mass | 517.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lucas SCC, et al. Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J Med Chem. 2024 Apr 11;67(7):5538-5566. |
E3 ligase Ligand 24
CAS: F: C21H26Cl2N4O5S W: 517.43
E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM). Due to E3 ligase Ligand
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