| Bioactivity | E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells[1]. |
| Invitro | E/Z-FETPY（72 小时）显示出细胞毒性潜力，可抑制 HCT 116、MCF7 和 A2780 细胞的生长，IC50 值分别为 4 μM、2.1 μM 和 2.5 μM[1]。E/Z-FETPY（2.5 μM；24-48 小时）显示在孵育 A2780 细胞后检测到铁摄取量随时间增加。 E/Z-FETPY 抑制过氧化氢 (H2O2) 和过氧亚硝酸盐 (O═NOO-)，同时增加超氧化物阴离子 (O2-) 和一氧化氮 (NO) 的产生[1]。FETPY (5 μM) 诱导小鼠 B16-F1 和 B16-F10 黑色素瘤细胞发生显著的形态变化，导致衰老和/或转分化为雪旺样细胞，从而显著降低其致瘤潜力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> E/Z-FETPY 相关抗体: |
| In Vivo | FETPY (4 mg/kg；腹腔注射；每天一次；持续 3 周) 显著降低两种模型中的生长率和肿瘤体积[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C22H24F3Fe2N2O5S2 |
| Molar Mass | 629.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ekatarina Mihajlović, et al. FETPY: a Diiron(I) Thio-Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. J Med Chem. 2024 May 9;67(9):7553-7568. |