| Bioactivity | Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual Dyrk1A and α-synuclein aggregation inhibitor with IC50 values of 177 nM and 10.5 µM, respectively. Dyrk1A/α-synuclein-IN-1 has high predictive CNS penetration and neuroprotective effect[1]. |
| Name | Dyrk1A/α-synuclein-IN-1 |
| Formula | C20H21N5O3S |
| Molar Mass | 411.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. AlNajjar, et al. Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects. European journal of medicinal chemistry 227 (2022): 113911. |
Dyrk1A/α-synuclein-IN-1
CAS: F: C20H21N5O3S W: 411.48
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual Dyrk1A and α-synuclein aggregation inhibitor with IC50 values of 177 n
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