| Bioactivity | Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC50=550 nM) and MAO B (IC50=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability[1]. |
| Invitro | Dual AChE-MAO B-IN-1 (compound 15) (1-100 μM) has no significant effect on the viability of human neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells even at concentration up to 100 μM[1].Dual AChE-MAO B-IN-1 (compound 15) (0.1-5 μM, 24 h) can reduce neuronal damage produced by Aβ1-42 and H2O2 and completely shut down N-methyl-d-aspartate (NMDA) toxicity in neuroblastoma cultures[1]. |
| Name | Dual AChE-MAO B-IN-1 |
| Formula | C23H25F2NO4 |
| Molar Mass | 417.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rullo M, et al. Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies. J Med Chem. 2022;65(5):3962-3977. |