| Bioactivity | DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect[1]. | ||||||||||||
| Target | DprE1 | ||||||||||||
| In Vivo | DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice[1]. Animal Model: | ||||||||||||
| Name | DprE1-IN-2 | ||||||||||||
| CAS | 1615713-87-5 | ||||||||||||
| Formula | C19H24N6O2 | ||||||||||||
| Molar Mass | 368.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Shirude PS et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37. |