| Bioactivity | Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. |
| Invitro | Doxycycline (0.01-10 µg/mL, 4 d) affects growth of glioma cells only under high concentrations[2].Doxycycline (0.01-10 µg/mL, 24 h) decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells[2].Doxycycline (100 ng/mL, 1 µg/mL; 24 h) reduces proliferation of human cell lines[4].Doxycycline (0-250 μM, 72 h) inhibits cell viability of breast cancer cells [5]. Cell Viability Assay[2] Cell Line: |
| Name | Doxycycline |
| CAS | 564-25-0 |
| Formula | C22H24N2O8 |
| Molar Mass | 444.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |