| Bioactivity | Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. |
| Invitro | Doxycycline hyclate (0.01-10 µg/mL, 4 d) affects growth of glioma cells only under high concentrations[2].Doxycycline hyclate (0.01-10 µg/mL, 24 h) decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells[2].Doxycycline hyclate (100 ng/mL, 1 µg/mL; 24 h) reduces proliferation of human cell lines[4].Doxycycline hyclate (0-250 μM, 72 h) inhibits cell viability of breast cancer cells [5]. Cell Viability Assay[2] Cell Line: |
| Name | Doxycycline (hyclate) |
| CAS | 24390-14-5 |
| Formula | C23H29ClN2O9 |
| Molar Mass | 512.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Doxycycline (hyclate)
CAS: 24390-14-5 F: C23H29ClN2O9 W: 512.94
Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycyclin
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