Dopamine D3 receptor ligand-5_product_DataBase

Bioactivity	Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively[1].
In Vivo	Dopamine D3 receptor ligand-5 (13a) 减少大鼠对可卡因的自发摄取 (FR2；1-10 mg/kg，腹腔注射)，这表明具有适度 D3R/D2R 选择性的部分激动剂/拮抗剂可能在治疗 PSUD (假性神经阻滞药物依赖) 和其他情感障碍的疾病中有效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2899250-94-1
Formula	C22H33Cl2N3O2
Molar Mass	442.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Emma S Gogarnoiu, et al. Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders. J Med Chem. 2023 Feb 9;66(3):1809-1834.

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