| Bioactivity | Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species, and triggers aggregation of α-synuclein. DOPAL elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2]. |
| CAS | 5707-55-1 |
| Formula | C8H8O3 |
| Molar Mass | 152.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9(1):42. [2]. Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5(5):1356-1367. |