| Bioactivity | Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1]. |
| Invitro | Domagrozumab (PF-06252616) 抑制人肌肉生长抑制素信号传导活性，IC50 值 为 < 1 nM[1]。 |
| In Vivo | Domagrozumab (PF-06252616; 10 and 30 mg/kg; i.v.) 以剂量依赖性方式增加肌肉生长抑制素水平并诱导食蟹猴骨骼肌肥大[1]。 |
| Name | Domagrozumab |
| CAS | 1629605-31-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. St Andre M, et, al. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys. Skelet Muscle. 2017 Nov 9;7(1):25. |