| Bioactivity | Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research[1][2]. |
| Invitro | Dolcanatide (0-10 μM; 30 min) activates GC-C receptors to stimulate cGMP synthesis in a dose-dependent manner in T84 cells[2].Dolcanatide (1 μM; 16 h) suppresses lipopolysaccharide-induced paracellular permeability in Caco-2 and T84 cells[1]. Cell Viability Assay[2] Cell Line: |
| Name | Dolcanatide |
| CAS | 1092457-65-2 |
| Formula | C65H104N18O26S4 |
| Molar Mass | 1681.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Dolcanatide
CAS: 1092457-65-2 F: C65H104N18O26S4 W: 1681.89
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and ant
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