Dodecylphosphocholine

Bioactivity Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins[1][2].
Invitro Dodecylphosphocholine micelles can be used to characterize pore formation the influenza M2 transmembrane (M2TM) domain by NMR spectroscopy[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Name Dodecylphosphocholine
CAS 29557-51-5
Formula C17H38NO4P
Molar Mass 351.46
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. de Haas GH, Dijkman R, Ransac S, Verger R. Competitive inhibition of lipolytic enzymes. IV. Structural details of acylamino phospholipid analogues important for the potent inhibitory effects on pancreatic phospholipase A2. Biochim Biophys Acta. 1990;1046(3):249-257. [2]. François Dehez, et al. Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity. Biophys J. 2017 Dec 5;113(11):2311-2315. [3]. Sarah D Cady, et al. Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc. 2011 Mar 30;133(12):4274-84.

Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins.

 

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