| Bioactivity |
Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins[1][2]. |
| Invitro |
Dodecylphosphocholine micelles can be used to characterize pore formation the influenza M2 transmembrane (M2TM) domain by NMR spectroscopy[2]. |
| Name |
Dodecylphosphocholine |
| CAS |
29557-51-5 |
| Formula |
C17H38NO4P |
| Molar Mass |
351.46 |
| Appearance |
Solid |
| Transport |
Room temperature in continental US; may vary elsewhere. |
| Storage |
| Powder |
-20°C |
3 years |
|
4°C |
2 years |
| In solvent |
-80°C |
6 months |
|
-20°C |
1 month |
|
| Reference |
[1]. de Haas GH, Dijkman R, Ransac S, Verger R. Competitive inhibition of lipolytic enzymes. IV. Structural details of acylamino phospholipid analogues important for the potent inhibitory effects on pancreatic phospholipase A2. Biochim Biophys Acta. 1990;1046(3):249-257. [2]. François Dehez, et al. Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity. Biophys J. 2017 Dec 5;113(11):2311-2315. [3]. Sarah D Cady, et al. Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc. 2011 Mar 30;133(12):4274-84. |
