| Bioactivity | Divarasib (GDC-6036) adipate is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state[1][2]. |
| Name | Divarasib adipate |
| CAS | 2762240-36-6 |
| Formula | C35H42ClF4N7O6 |
| Molar Mass | 768.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lingyao Meng, et al. Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach. Anal Chem. 2022 Sep 20;94(37):12927-12933. [2]. Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2. |
Divarasib adipate
CAS: 2762240-36-6 F: C35H42ClF4N7O6 W: 768.20
Divarasib (GDC-6036) adipate is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of
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