| Bioactivity | Disoxaril (WIN-51711) is a polioviruses inhibitor. Disoxaril inhibits the replication of polioviruses types 1 and 2 in cells. Disoxaril binds directly to the virion capsid proteins and inhibits viral uncoating by stabilizing the virus capsid. Disoxaril still allows the virus to enter the cell by receptor-mediated endocytosis. Disoxaril also inhibits enterovirus replication[1][2]. |
| CAS | 87495-31-6 |
| Formula | C20H26N2O3 |
| Molar Mass | 342.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zeichhardt H, et al. Inhibition of poliovirus uncoating by disoxaril (WIN 51711). Virology. 1987 Sep;160(1):281-5. [2]. Nikolova I, et al. Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene. Z Naturforsch C J Biosci. 2011 Nov-Dec;66(11-12):627-36. |