Diquafosol_product_DataBase

Bioactivity	Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye[1].
Invitro	Diquafosol (3%; 24 h) 可抑制干燥条件下 hCEC 细胞凋亡并减少 ROS 生成[1]。Diquafosol (3%; 24 h) 可增加 hCEC 中磷酸化 Erk1/2、磷酸化 Akt 和磷酸化 p90RSK 的蛋白质表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Diquafosol 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Diquafosol (ophthalmic solution 3%; eyedrop, four times daily for 28 days) 可降低大鼠细胞内的 ROS 水平、细胞凋亡和炎症[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	59985-21-6
Formula	C18H26N4O23P4
Molar Mass	790.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Park JH, et al. Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5108-5115.

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