| Bioactivity | Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive immune response[1]. | ||||||||||||
| Invitro | Diprovocim-X stimulates release of TNF-α from (human) differentiated THP-1 cells proves dependent on both TLR2 and TLR1, but notably independent of TLR6[1]. | ||||||||||||
| Name | Diprovocim-X | ||||||||||||
| Formula | C66H83N7O10 | ||||||||||||
| Molar Mass | 1134.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yang MH, et al. Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. J Med Chem. 2022 Jun 29. |