Diphlorethohydroxycarmalol_product_DataBase

Bioactivity	Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities[1].
Target	IC50: 0.16 mM (α-glucosidase) and 0.53 mM (α-amylase)
In Vivo	The increase of postprandial blood glucose levels are significantly suppressed in the Diphlorethohydroxycarmalol-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) is significantly reduced via Diphlorethohydroxycarmalol (100 mg/kg; p.o.) administration (2022 versus 2210 mmol x min/lL) in the diabetic mice as well as it delays absorption of dietary carbohydrates[1].
Name	Diphlorethohydroxycarmalol
CAS	138529-04-1
Formula	C24H16O13
Molar Mass	512.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Soo-Jin Heo, et al. Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol. 2009 Aug 1;615(1-3):252-6.

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