| Bioactivity | Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1]. |
| Invitro | Effects of these compounds (10 microM) on the membrane potential of HEKBKalphabeta1 were monitored by use of DiBAC(4)(3), a voltage-sensitive dye. Dihydroisopimaric acid induces substantial membrane hyperpolarization. Dihydroisopimaric acid (1-10 microM) activates BKalphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1]. |
| Name | Dihydroisopimaric acid |
| CAS | 5673-36-9 |
| Formula | C20H32O2 |
| Molar Mass | 304.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Imaizumi Y, et al. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Mol Pharmacol. 2002;62(4):836-846. |
Dihydroisopimaric acid
CAS: 5673-36-9 F: C20H32O2 W: 304.47
Dihydroisopimaric acid activates large conductance Ca2+activated K+ (BK) channels alphabeta1 in the direct measurement o
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