Dihomo-γ-linolenic acid_product_DataBase

Bioactivity	Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].
Invitro	Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages[2].Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727[2].Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages[2].Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation[2].Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages[2].Dihomo-γ-linolenic acid modulates mitochondrial respiration[2].Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC[2]. Western Blot Analysis[2] Cell Line:
Name	Dihomo-γ-linolenic acid
CAS	1783-84-2
Formula	C20H34O2
Molar Mass	306.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Solution, -20°C, 2 years

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