| Bioactivity | Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM)[1]. | ||||||||||||
| In Vivo | Diflapolin (1-10 mg/kg; i.p.; 30 min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments[1]. Animal Model: | ||||||||||||
| Name | Diflapolin | ||||||||||||
| CAS | 724453-98-9 | ||||||||||||
| Formula | C22H17Cl2N3O2S | ||||||||||||
| Molar Mass | 458.36 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Garscha U, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7(1):9398. Published 2017 Aug 24. |
Diflapolin
CAS: 724453-98-9 F: C22H17Cl2N3O2S W: 458.36
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor wi
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.