| Bioactivity | Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth[1]. | ||||||||||||
| Invitro | Difenoconazole 抑制禾谷镰刀菌 (Fusarium graminearum) 生长，EC50 为 1.69 ~ 19.6 mg/L[2]。Difenoconazole 抑制加链格孢 (Alternaria solani)、茄子叶霉病菌 (Fulvia fulva)、贵腐霉菌 (Botrytis cinerea)、立枯丝核菌 (Rhizoctonia solani) 的生长，EC50s 分别为 0.131、0.069、0.297 和 0.252 mg/L[2]。 | ||||||||||||
| In Vivo | Difenoconazole (0.25-2 mg/L; 暴露 96 h) 会导致斑马鱼胚胎发育中的一系列症状，包括发育抑制、心率减慢、生长退化和形态畸形[1]。 Animal Model: | ||||||||||||
| Name | Difenoconazole | ||||||||||||
| CAS | 119446-68-3 | ||||||||||||
| Formula | C19H17Cl2N3O3 | ||||||||||||
| Molar Mass | 406.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Mu X, et al. Evaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assays. Environ Pollut. 2013 Apr;175:147-57. [2]. Dong F, et al. Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. Environ Sci Technol. 2013 Apr 2;47(7):3386-94. |
Difenoconazole
CAS: 119446-68-3 F: C19H17Cl2N3O3 W: 406.26
Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal
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