Didanosine_product_DataBase

Bioactivity

Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV[1][2][3].

Invitro

Didanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours[1].Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection[3].Didanosine (5, 10, 50, 100 ug/ml; 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells[2]. Cell Proliferation Assay[2] Cell Line:

In Vivo

Didanosine (100, 150 mg/kg; p.o.; daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse[2]. Animal Model:

Name

Didanosine

CAS

69655-05-6

Formula

C10H12N4O3

Molar Mass

236.23

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Munir N.Nassar, et al. Analytical profiles of drug substances and excipients. Journals & Books, 1993, 185-227. [2]. Braga Neto MB, et al. Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice. BMC Gastroenterol. 2010 Aug 11;10:90. [3]. Caroline M. Perry, et al. Didanosine. Drugs, 1999, 58, 1099-1135.

PeptideDB

Didanosine

CAS: 69655-05-6 F: C10H12N4O3 W: 236.23