Diclofenac epolamine_product_DataBase

Bioactivity	Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID)[1]. Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies[2].
Invitro	Flector Patch (Diclofenac epolamine) (1.3% w/w, 24 hours) increases diclofenac partitioning into the skin[1].Flector Patch (Diclofenac epolamine) (1.3% w/w) loaded by Microemulsion (ME) enhances the transport of drug through skin and sustains to 12 h after removal of ME[2].
In Vivo	Flector Patch (Diclofenac epolamine) (1.3% w/w, exteral application) displays effective in treating inflammatory conditions[2]. Animal Model:
Name	Diclofenac epolamine
CAS	119623-66-4
Formula	C20H24Cl2N2O3
Molar Mass	411.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Del Río-Sancho S, et al. Topical delivery of diclofenac into and across equine skin from a novel liquid diclofenac epolamine formulation. J Vet Pharmacol Ther. 2016 Dec. 39(6):578-583. [2]. Fouad SA, Basalious EB, El-Nabarawi MA, Tayel SA. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation. Int J Pharm. 2013 Sep 10;453(2):569-78.

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