| Bioactivity | DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1]. | ||||||||||||
| Invitro | DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1].DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1].DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1]. RT-PCR[1] Cell Line: | ||||||||||||
| Name | DiMNF | ||||||||||||
| CAS | 14756-24-2 | ||||||||||||
| Formula | C21H16O4 | ||||||||||||
| Molar Mass | 332.35 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Murray IA, et al. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol Pharmacol. 2011 Mar;79(3):508-19. |