| Bioactivity | Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate hydrate shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2]. | ||||||||||||
| Target | IC50: 47.3 nM (hSERT), 531.3 nM (hNET). | ||||||||||||
| Invitro | Desvenlafaxine succinate hydrate has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine succinate hydratealso induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme[2]. | ||||||||||||
| In Vivo | Desvenlafaxine succinate hydrate (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis[1]. Animal Model: | ||||||||||||
| Name | Desvenlafaxine succinate hydrate | ||||||||||||
| CAS | 386750-22-7 | ||||||||||||
| Formula | C20H33NO7 | ||||||||||||
| Molar Mass | 399.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Darlene C Deecher, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. [2]. Michael A Sopko Jr, et al. Desvenlafaxine: another "me too" drug? Ann Pharmacother. 2008 Oct;42(10):1439-46. |
Desvenlafaxine succinate hydrate
CAS: 386750-22-7 F: C20H33NO7 W: 399.48
Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B01
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.