| Bioactivity | Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay. |
| CAS | 253688-61-8 |
| Formula | C26H27N5O6S |
| Molar Mass | 537.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. van Giersbergen, et al. Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. Br. J. Clin. Pharmacol. 54(5), 561-562 (2002). |
Desmethyl Bosentan
CAS: 253688-61-8 F: C26H27N5O6S W: 537.59
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosenta
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