| Bioactivity | Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1]. | ||||||
| Invitro | Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2]. | ||||||
| Name | Dermorphin | ||||||
| CAS | 77614-16-5 | ||||||
| Sequence | Tyr-{d-Ala}-Phe-Gly-Tyr-Pro-Ser-NH2 | ||||||
| Shortening | Y-{d-Ala}-FGYPS-NH2 | ||||||
| Formula | C40H50N8O10 | ||||||
| Molar Mass | 802.87 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Dermorphin
CAS: 77614-16-5 F: C40H50N8O10 W: 802.87
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic
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