| Bioactivity | Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome[1]. |
| CAS | 1457983-33-3 |
| Formula | C25H26BrClN6O2 |
| Molar Mass | 557.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim DK, et al. Denfivontinib activates effector T-cells through NLRP3-inflammasome, yielding potent anticancer effects by combination with pembrolizumab. Mol Cancer Ther. 2024 Dec 5. |
Denfivontinib hydrochloride
CAS: 1457983-33-3 F: C25H26BrClN6O2 W: 557.87
Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor P
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