| Bioactivity | Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections[1][2]. |
| Invitro | Demeclocycline (0-100 μM; 24 h) treatment reduces AQP2 abundance in mpkCCD cells[3].Demeclocycline (10 μM; 24 h) treatment promotes the activity of monocytes and macrophages[4].Demeclocycline (1-10 μM; 72 h) treatment directly affects the growth of brain tumorinitiating cells[4]. Western Blot Analysis[3] Cell Line: |
| Name | Demeclocycline |
| CAS | 127-33-3 |
| Formula | C21H21ClN2O8 |
| Molar Mass | 464.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Demeclocycline
CAS: 127-33-3 F: C21H21ClN2O8 W: 464.85
Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 3
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