| Bioactivity | Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors[1]. |
| Target | KD: 203 pM (PDE6δ-KRas) |
| Invitro | Deltasonamide 1 可以抑制 PDE6δ-KRas，KD 为 203 pM[1]。Deltasonamide 1 通过多达 7 个氢键与 PDE6δ 结合，产生皮摩尔亲和力[1]。Deltasonamide 1 强烈减少增殖[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | Deltasonamide 1 TFA |
| CAS | 2235358-73-1 |
| Formula | C32H40ClF3N6O6S2 |
| Molar Mass | 761.27 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Pablo Martín-Gago, et al. A PDE6δ-KRas Inhibitor Chemotype With Up to Seven H-Bonds and Picomolar Affinity That Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. |
Deltasonamide 1 TFA
CAS: 2235358-73-1 F: C32H40ClF3N6O6S2 W: 761.27
Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonami
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