| Bioactivity | Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction[1]. |
| In Vivo | Delequamine (0.4-6.4 mg/kg; 口服，单剂量) hydrochloride 在未经过训练的雄性大鼠与经过雌激素-孕激素处理、性接受状态的雌性大鼠接触的模型中能以剂量依赖的方式增加性行为评分。并且 Delequamine (0.4 mg/kg; 口服; 单剂量) hydrochloride 和 8-OH-DPAT (HY-112061) ( 0.1 mg/kg; 皮下注射) 联用能增加大鼠爬跨、插入和射精的百分比，缩短了射精潜伏期并减少插入次数[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 119942-75-5 |
| Formula | C18H27ClN2O3S |
| Molar Mass | 386.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tallentire D, et al. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996;118(1):63-72. |
Delequamine hydrochloride
CAS: 119942-75-5 F: C18H27ClN2O3S W: 386.94
Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pKi
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