| Bioactivity | Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3]. |
| Target | COX-2 |
| Name | Dehydroglyasperin D |
| CAS | 517885-72-2 |
| Formula | C22H24O5 |
| Molar Mass | 368.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33(5):917-21. [2]. Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19(1):135-42. [3]. Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32(8):982-988. |
Dehydroglyasperin D
CAS: 517885-72-2 F: C22H24O5 W: 368.42
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydrogly
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