| Bioactivity | Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus.IC50 value:Target:In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression.In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3]. | ||||||||||||
| Name | Dehydrocostus Lactone | ||||||||||||
| CAS | 477-43-0 | ||||||||||||
| Formula | C15H18O2 | ||||||||||||
| Molar Mass | 230.30 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Dehydrocostus Lactone
CAS: 477-43-0 F: C15H18O2 W: 230.30
Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus.IC50 value:Target:In
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